However, Shi et al. discovered that a deficiency of KLF4 in mouse bone marrow decreased the incidence of lung metastasis (Shi et al., 2014).We found that the E-cadherin expression was decreased, while the vimentin expression was increased in NSCLC tissues and metastatic lung cancer tissues in the trachea and main bronchus. The gene discussed is KLF4; the disease is non-small cell lung carcinoma.