However, Shi et al. discovered that a deficiency of KLF4 in mouse bone marrow decreased the incidence of lung metastasis (Shi et al., 2014).We found that the E-cadherin expression was decreased, while the vimentin expression was increased in NSCLC tissues and metastatic lung cancer tissues in the trachea and main bronchus. This evidence concerns the gene CDH1 and non-small cell lung carcinoma.