Uncoupling protein 2 (UCP2) has a role in regulating lipid efflux and oxidative metabolism, and homozygous 866 G > A is associated with increased hepatic protein levels and reduced risk of NASH (adjusted OR: 0.49, 95% CI: 0.26–0.90, p = 0.02) (Fares et al., 2015). This evidence concerns the gene UCP2 and metabolic dysfunction-associated steatohepatitis.