MBOAT7 is highly expressed in hepatocytes, hepatic stellate cells, and hepatic sinusoidal cells, and the rs641738 T allele increases risk of hepatic triglyceride content and NAFLD spectrum, with each T allele increasing the risk of steatosis (OR: 1.42, 95% CI 1.07–1.91, p = 0.015), NASH (OR: 1.18, 95% CI 1.00–1.40, p = 0.05), hepatic fibrosis stage F2-4 (OR: 1.30, 95% CI 1.06–1.70, p = 0.012), and HCC in the absence of advanced fibrosis (OR: 2.10, 95% CI 1.33–3.31) (Buch et al., 2015; Mancina et al., 2016; Donati et al., 2017). This evidence concerns the gene MBOAT7 and metabolic dysfunction-associated steatotic liver disease.