PPP1R3B and fatty liver disease: PPP1R3B rs4240624 is associated with CT-diagnosed hepatic steatosis, but not histological evidence of inflammation and fibrosis (Speliotes et al., 2011) and the PPP1R3B rs61756425 variant is a strong predictor of severe NAFLD on ultrasound (OR: 32.6, 95% CI 4.22–251.4, p = 0.001) (Di Costanzo et al., 2018).