PNPLA3 and coronary artery disorder: Interestingly, presence of PNPLA3 I148M variant has been shown to confer a small, but significant risk of premature CAD (defined as MI, angioplasty, revascularization surgery, coronary stenosis >50% diagnoses before the age of 55 in men, and 65 in women) only in those with T2DM (OR 1.20, 95% CI 1.01–1.42, p = 0.042), in a study of 1,103 individuals with premature CAD and 1,469 healthy controls (Posadas-Sánchez et al., 2017).