PNPLA3 and coronary artery disorder: A recent prospective study of patients undergoing elective coronary angiography found that while there was a non-significant trend for a protective effect of the presence of PNPLA3 I148M and CAD >75% stenosis, when corrected for age, sex, use of statins, and serum high-density lipoprotein, there was a significant protective effect (OR: 0.21, 95% CI 0.05–0.88, p = 0.03) (Rüschenbaum et al., 2018).