ADIPOQ and Alzheimer disease: Serum adiponectin was 33% higher in AD when compared to MCI patients. Adiponectin CSF levels, similar in both groups, were positively correlated with Aβ42 and cognitive function, though only in women. The area under the ROC curve was 0.673 (95% CI: 0.57–0.78) for serum adiponectin as predictor of dementia stage and the cutoff 10.85 μg/ml maximized the sum of specificity (87%) and sensitivity (44%).