Changes in the distribution and diversity of GluR’s are a hallmark of synaptic plasticity and the progression of epilepsy (Bonansco and Fuenzalida, 2016), so it is possible that NP2, given its upregulation in MECS, may be involved in establishing these long-term AMPA-dependent changes at the synapse in epilepsy. Here, NPTX2 is linked to epilepsy.