In addition, there exists increased transcription and translation of UPRmt associated genes in the brain of familial and sporadic AD patients, e.g., upregulation of hspd1 (HSP60) and clpp (CLPP mitochondrial protease) genes, but not lon1p1 (the LONP1 mitochondrial protease; Beck et al., 2016). Here, CLPP is linked to Alzheimer disease.