The myriad of functions attributed to the Rab proteins and the varied hypothesized routs to pathogenesis in PD can be summarized as the following three pathways: endocytic function and lysosomal stress, ciliogenesis and sonic hedgehog signaling and, lastly the trans-Golgi network and endoplasmic reticulum (ER) stress. Here, AGFG1 is linked to Parkinson disease.