Genes like GNAS, which was reported to be closely related to the development of pancreatic cyst51 and intraductal papillary mucinous neoplasm (IPMN)-associated invasive adenocarcinoma52 and might serve as an alternative oncogene in KRAS wild-type PDAC,49 were not included and needed to be paid more attention in further study. This evidence concerns the gene KRAS and pancreatic intraductal papillary-mucinous neoplasm.