TACSTD2 and neoplasm: Sacituzumab govitecan (IMMU-132, Immunomedics) is an ADC that consists of a humanized anti-trophoblast cell surface antigen (Trop-2) antibody, conjugated with active metabolite of irinotecan (SN-38) through the cleavable CL2A linker that is subject to time dependent hydrolysis supporting the bystander effect in the tumor environment7.