TPX2 and cancer: A3 1–31 Mb included all genes comprised in a gene signature of 18 genes (i.e. TPX2, DLGAP4, DSN1, RBL1, FAM83D, MYBL2, PABPC1L, UBE2C, CTSA, MMP9, SULF2, CSE1L, SALL4, ZNF217, PFDN4, AURKA, RAE1, and PMEPA1) associated with poor prognosis in many human cancer types51.