F2 64–82.3 Mb (human homologue region located in HSA 8q) was significant in multivariate analysis and harboured several breast cancer-related genes affected by CNGs in HBCs19,28,41 including EMT-related genes (i.e. MYC, SCRIB, NDRG1, and PTK2) commonly affected by CNGs in multiple human cancer types21 (Tables 3 and 4), among them, MYC amplification is validated as somatic-CNG by the Cancer Gene Census (CGC)59. The gene discussed is SCRIB; the disease is breast cancer.