Significantly increased levels of circulating miR-330-3p were also observed in GDM patients treated by diet (median [IQR], 946252 [484236–1517000] copies, n = 12) but not those treated by insulin (median [IQR], 59518 [12967–1355000] copies, n = 19) when compared to nondiabetic controls (median [IQR], 20098 [8734–50016] copies, n = 29; p = 0.004, Kruskal-Wallis test)(Fig. 3). The gene discussed is INS; the disease is gestational diabetes.