E2F1 and Hyperglycemia: To examine potential mechanisms though which miR-330-3p might mediate such processes in the control of hyperglycaemia, Sebastiani et al. highlighted two experimentally validated targets of miR-330-3p: E2F transcription factor 1 (E2F1), facilitating glucose homeostasis through upregulation of beta-cell proliferation, insulin secretion and glucose tolerance51, and cell division cycle 42 (CDC42), a potent modulator of insulin secretion and importantly, second-phase insulin release52,53.