We also found that either ER stress inhibitor (salubrinal, 12.5 nmol/eye) or unfolded protein response modulators (the XBP-1 inhibitor ansatrienin A, 1 nmol/eye; the GSK 3b inhibitor TDZD-8, 1 and 20 nmol/eye) had no effect on rotenone-induced retinal degeneration (see Supplementary Fig. S4). The gene discussed is XBP1; the disease is retinal degeneration.