Of note, in CIA, myeloid populations including osteoclast precursors were unaffected by arginine restriction, as was the systemic RANKL/OPG ratio in all models studied (Supplementary Fig. 1g–i), suggesting that decreased osteoclast numbers found in arthritis were due to differentiation of osteoclasts. The gene discussed is TNFRSF11B; the disease is arthritic joint disease.