There was a significant increase in IFN-γ secretion by pp65-TCR T-cells when they encountered DCs co-cultured with SFV4-infected HOS-copGFP-pp65 cells (Fig. 4j), indicating that DCs could take up tumor-associated antigens (in this case the pp65 model antigen) from SFV4-infected and dying tumor cells and cross-present antigenic peptides to activate antigen-specific CD8+ T-cells. The gene discussed is CD8A; the disease is neoplasm.