SENP1 and neoplasm: Notably, data mining of RNA-seq and clinical data that are publically available in The Cancer Genome Atlas (TCGA) database (https://cancergenome.nih.gov/, dataset: TCGA-LIHC) confirmed that SENP1 expression is upregulated in tumor tissues (50 normal tissues vs. 374 tumor tissues, or 50 normal tissues vs. 50 matched tumor tissues, P < 0.001) and associated with lower survival rate (Figure 1E–1G).