COL5A2 has been reported as specific predictive signature for the diagnosis and prognosis of pancreatic cancer [25] and bladder cancer [26].We also visualized the differentially expressed proteins on heatmaps and used gene ontology (GO) analysis (Blast2Go, https://www.blast2go.com/) to annotate biological function. Here, COL5A2 is linked to familial pancreatic carcinoma.