Using Nav1.8-positive nociceptor-specific knockouts for Hcn2 (instead of global Hcn2 knockouts, because those were extremely unhealthy), the same group further showed that HCN2 is activated in the same manner and contributes to heat, but not mechanical, hyperalgesia in a PGE2 injection model, carrageenan-inflammation model, and CCI neuropathy model [185]. This evidence concerns the gene HCN2 and neuropathy.