The aberrant accumulation of p62 has been detected in the cases of gastrointestinal cancer [214], prostate cancer [215, 216], hepatocellular carcinoma [217–219], breast cancer [220, 221], lung adenocarcinoma [222], suggesting that p62 accumulation correlates with cancer progression and autophagy suppresses tumorigenesis by limiting p62 accumulation [213, 223, 224]. Here, SQSTM1 is linked to hepatocellular carcinoma.