Because of metabolism and immune system dysfunction, compared to non-dialysis, patients undergoing dialysis are more susceptible to suffer from elevated highly sensitive C-reactive protein (hs-CRP), interleukin 6 (IL-6), and cholesterol levels, and decreased serum albumin (Alb) levels, which contributed to an increased risk of cardiovascular disease (CVD), atherosclerosis, malnutrition and chronic periodontitis (CP). This evidence concerns the gene IL6 and periodontitis.