The purpose of this network meta-analysis is to compare the efficacy of SGLT-2 inhibitors, DPP-4 inhibitors, GLP-1 agonists, MET, sulfonylurea (SU) and thiazolidinediones (TZDs) in improving LV remodeling in patients with T2DM and/or CVD. This evidence concerns the gene GCG and type 2 diabetes mellitus.