The purpose of this network meta-analysis is to compare the efficacy of SGLT-2 inhibitors, DPP-4 inhibitors, GLP-1 agonists, MET, sulfonylurea (SU) and thiazolidinediones (TZDs) in improving LV remodeling in patients with T2DM and/or CVD. The gene discussed is SLC5A2; the disease is type 2 diabetes mellitus.