Of note, in 2018, a network meta-analysis involving 236 studies and 176,310 subjects found that GLP-1 agonists and SGLT-2 inhibitors were significantly associated with lower cardiovascular mortality than were the control treatments, and SGLT-2 inhibitors were associated with a reduction in heart failure events and myocardial infarction. This evidence concerns the gene SLC5A2 and myocardial infarction.