AFP and chronic hepatitis B virus infection: There are, however, some helpful features to distinguish HCC with HBDTTs from hilar CCs that were found in our study, including a younger male predominance with a history of chronic hepatitis B infection, upper abdomen pain, elevated level of AFP, washout in portal phase, normal thickness of hilar bile duct wall without abnormal enhancement, vascular tumor embolus, enlargement of lymph nodes and splenomegaly.