Most genes located within these loci are affected by somatic mutations occurring in gliomas, namely cyclin-dependent kinase inhibitor 2A and B (CDKN2A, CDKN2B), epidermal growth factor receptor (EGFR), telomerase reverse transcriptase (TERT), TP53, pleckstrin homology-like domain family B member 1 (PHLDB1), and regulator of telomere elongation helicase 1 (RTEL1) [26,27,28,35,36,37,38]. The gene discussed is RTEL1; the disease is central nervous system cancer.