For example, high-grade gliomas are associated with risk variants in RTEL1, CDKN2B, and TERT [32,38], while low-grade gliomas with IDH mutation-1p/19q codeletion are associated with risk variants in CCDC26 and PHLDB1 regions [17,32,38]. The gene discussed is CCDC26; the disease is central nervous system cancer.