CDKN2B and central nervous system cancer: Furthermore, CDKN2A germline mutations are responsible for the melanoma-astrocytoma syndrome (MIM number 155755), and genetic variants close to both CDKN2A and CDKN2B genes (on the chromosomal locus 9p21) are known to increase the risk for glioma, basal cell carcinoma, and melanoma [35].