Low levels of COX16 expression were correlated with improved survival in patients with HPV+ (p = 0.0080, FDR = 0.092) (Figure 3E), but not in patients with HPV- HNSCC (p = 0.33, FDR = 0.59) (Figure 3F). This evidence concerns the gene COX16 and head and neck squamous cell carcinoma.