TPT1 and colorectal cancer: It was also suggested that TCTP regulates metastasis of colorectal cancer by regulation of the high mobility group 1 (HMGB1) and activation of the NF-KB pathway [17], or by regulating epithelial-mesenchymal transition (EMT) via mammalian target of the rapamycin complex 2 (mTORC2)/Akt/GSK3β/β-catenin pathway [15].