PD-L1 so far is the only ICB biomarker for which FDA has approved a companion test for pembrolizumab (anti-PD-1) treatment in patients with NSCLC, gastric or gastroesophageal junction adenocarcinoma, cervical cancer, and urothelial carcinoma (PD-L1 IHC 22C3 pharmDx). This evidence concerns the gene CD274 and cervical carcinoma.