Regarding the tumor-intrinsic reprogramming that features the immunosuppressive TME, it has been reported that DNA methylation at the promoter regions of the tumor Th1-type chemokines CXCL9 and CXCL10, mediated by DNMT1, represses their transcript and protein expression in ID8 ovarian cancer in C57/BL6 mice. This evidence concerns the gene DNMT1 and neoplasm.