Consistent with a previous study, SLC16A11 rs75493593, a Native American-derived variant, was identified as the main contributor to T2D in Mexicans and accordingly, its frequency was higher as compared to other populations (f risk allele G: 34.4% in this study, 1.7% in Europeans, 0.3% in Africans and 10% in East Asians). Here, SLC16A11 is linked to type 2 diabetes mellitus.