There was no significant effect of the IVS2+114G>A SNP of TGFB1, while the CC genotype IVS1-1284G>C SNP of TGFB3 was associated with an increased risk of DCM development (OR 1.46, p = 0.044). This evidence concerns the gene TGFB1 and familial dilated cardiomyopathy.