Serum exo-miR-10b-5p revealed a significant diagnostic accuracy for early-stage HCC, while AUC of serum AFP and serum exo-miR-215-5p was 0.542 (sensitivity = 9.4%, specificity = 71.6%) and 0.666 (sensitivity = 25.0%, specificity = 88.6%), respectively (Figure 4d, Table 2). Here, AFP is linked to hepatocellular carcinoma.