MBD1 and neoplasm: MBD1, which was a transcriptional regulator that could repress the tumour suppressor genes through binding their methylated CpG islands, was strongly suggested to promote tumorigenesis.6 In PDAC, silencing MBD1 expression using RNAi would dramatically inhibit cell growth and induce cell apoptosis.7 More detailed studied also revealed that the MBD1 could affect the invasion, metastasis sensitivity of cells to radiation and chemical therapy in PDAC.31, 32 Our study incorporated the MBD1siRNA plasmid into the carbon nanotube carriers to confirm the therapeutic effect in PDAC.