SIRT1 and obesity due to melanocortin 4 receptor deficiency: In this context, miR‐22 is known to directly target peroxisome proliferative activated receptor, gamma, coactivator 1 alpha (Pgc‐1α), peroxisome proliferator‐activated receptor α (Pparα) and Sirtuin 1 (Sirt1),42, 43 which are important genes involved in fatty acid metabolism, mitochondrial biogenesis and obesity.