Taken together, our data suggest that IL-15 or other means of inducing T cell autophagy may constitute a useful strategy to promote highly functional T cells with the capacity to reside in the liver and resist mitochondrial depolarization, for example, in the optimization of adoptive T cell therapy for hepatocellular carcinoma (HCC) (Qasim et al., 2015). This evidence concerns the gene IL15 and hepatocellular carcinoma.