IL-15 has also been used for optimal expansion of antigen-specific T cells in vivo in melanoma models (Zeng et al., 2005), for stem-cell-like chimeric antigen receptor T (Tscm) cells (Hurton et al., 2016), and is crucial for persistence of inflationary MCMV-specific T cells (Baumann et al., 2018). This evidence concerns the gene IL15 and melanoma.