STING1 and viral infectious disease: For example, phosphorylation of MITA at Ser358 and Ser366 is crucial for its activation and recruitment of IRF3 [18, 26, 27]; sumoylation of MITA in the early phase of viral infection by TRIM38 promotes its stability and activation whereas desumoylation of MITA in the late phase by SENP2 leads to its degradation thus avoiding sustained activation of MITA [29].