We found that the proportion of higher-order GLCM and RLM features in each feature cluster were rather high (Ki-67: 60%; S-100: 80%; vimentin: 100%; CD34: 100%; high and low grade gliomas: 100%), which indicating that radiomics features were more effective than the traditional image morphology features. The gene discussed is MKI67; the disease is central nervous system cancer.