However, this positive result is also possible for other vascular lesions, including epitheloid hemangioendotheliomas, angiosarcomas, and angiokeratomas; so, the final diagnosis for HEM should be made through the interpretation of all clinical and diagnostic features, and not based on GLUT-1 staining alone (6,39). The gene discussed is SLC2A1; the disease is Greenberg dysplasia.