The inhibitory effects of midostaurin on phosphorylation of AKT, S6 and MAPK in wt FLT3‐expressing AML are similar to those observed with midostaurin‐treated, mutant FLT3‐positive MOLM14 cells; however, strong inhibition of these molecules was observed at concentrations less than 100 nmol/L in the mutant FLT3‐expressing cells (Figure S1G). Here, FLT3 is linked to acute myeloid leukemia.