As midostaurin causes loss of proviability signalling molecules, such as Mcl‐1 and Bcl‐xL, we propose that the direct effect of midostaurin on the apoptotic machinery of AML cells (as shown in Figure 2), in addition to the drug's broad spectrum of targets that includes molecules such as KIT, PDGFR, VEGFR and SYK, may contribute to the widespread synergizing potential of midostaurin. Here, SYK is linked to acute myeloid leukemia.