Instead, this could be due to signals of glucose metabolism deterioration as reflected by significantly (p < .001) higher proinsulin levels and higher average blood glucose (determined by HbA1c‐levels) in the LF phenotypes (1/116 HF and 20/91 LF subjects had higher than normal ranges of proinsulin (chi‐squared p < .001), 10/116 HF and 30/91 LF had higher ranges than those recommended for HbA1c (Gardner & Shoback, 2011) (chi‐squared p < .001), see Table S3). The gene discussed is INS; the disease is hydrops fetalis.