HOXA10 belongs to the homeobox gene family that is well conserved during evolution and plays a vital role in several biological processes.12 A competing endogenous RNA network analysis showed that lncRNA ENSG00000240990 competed with HOXA10 to affect the prognosis of lung adenocarcinoma patients.13 Furthermore, HOXA10 with recurrent up‐regulation has been documented in human lung cancer cells and tissues.14 Base on the aforementioned literature, we hypothesized that LINC00461 may be involved in lung adenocarcinoma by regulating HOXA10 via miR‐195. This evidence concerns the gene LBX1 and lung adenocarcinoma.