Through transcriptomic and proteomic analyses of m6A‐associated molecules in large HB cohorts, including RNA‐seq data from public GEO microarray platform and IHC staining results from the TMA ZZU cohort, we found that m6A‐related genes were frequently dysregulated in HB and that the upregulation of METTL3 expression was an independent survival risk factor for HB (Figures 1,2 and 3A). Here, METTL3 is linked to hemoglobin measurement.