Besides systematic evaluation of the existing subtype classifiers, special protein expression patterns also could gain us insights into their impacts on thymus functions and T‐cell maturation, particularly (a) proteins such as PRSS16 and PSMB11, which were closely related to thymus function and played pivotal roles in development of CD8‐positive T cell, showed in considerable quantity in thymoma samples of all major subtypes (compared with TSCC samples). The gene discussed is CD8A; the disease is thymoma.