However, in studies with other cancer types, CNOT2 was also reported to play roles in promoting tumor progression (Gupta et al., 2017; Paone et al., 2014; Sohn et al., 2018), possibly by downregulation of MHC II expression as evidenced in several cell line and animal models (Rodriguez‐Gil et al., 2017), therefore undermined immunosurveillance of cancer. The gene discussed is CNOT2; the disease is neoplasm.