In RA, several studies determined the frequency of aCL and aβ2GPI.5, 6, 7, 8, 9, 10, 11 However, to our knowledge, aβ2GPI‐IgA has been determined in only three studies.7, 8, 9 Furthermore, the frequency of aPL antibodies is not known in RA in Tunisia. This evidence concerns the gene ACLY and rheumatoid arthritis.