Multivariate logistic regression analysis revealed that both miR‐125a and miR‐125b failed to predict ARDS risk independently, while only COPD (OR = 5.762, P = .010), CRP (OR = 1.010, P = .014), and APACHE II score (OR = 1.122, P = .042) were independent predictive factors for higher ARDS risk in sepsis patients (Table 2). This evidence concerns the gene CRP and acute respiratory distress syndrome.