We have previously shown that ApN possesses powerful anti‐inflammatory effects on skeletal muscle exposed to acute (lipopolysaccharide injection)7 and chronic (obesogenic diet) inflammation.8 We have then tested the implication of ApN in DMD and found that mdx mice (a murine model of DMD) display low circulating ApN levels.9 When we crossed mdx mice with transgenic mice overexpressing ApN, we showed that ApN can act as preventive agent and delay disease progression. Here, ANPEP is linked to Duchenne muscular dystrophy.