INS and obesity due to melanocortin 4 receptor deficiency: Furthermore, AdipoRon appears to be safe in mice: it did not impair but rather protected liver and renal function.13, 38 Moreover, unlike GCs, AdipoRon enhanced insulin sensitivity,12 prevented obesity,16 hypertension,15 and mood disturbances,16 and even increased the lifespan of obese mice.12