INS and obesity due to melanocortin 4 receptor deficiency: It promotes insulin‐sensitizing, fat‐burning, and anti‐inflammatory/oxidative actions, thereby effectively counteracting several metabolic disorders, including type 2 diabetes, obesity, and cardiovascular disease.4, 5 ApN exerts its pleiotropic effects by modulating different signalling pathways in a variety of cell types,5 including the skeletal muscle.6