These results are in agreement with our previous work carried out on transgenic mdx mice with chronic overexpression of ApN, where ApN up‐regulation helped rescue the dystrophic phenotype.9 Likewise, ApN added to cultured myotubes of DMD patients induced a shift in the secretion of downstream myokines towards a less inflammatory profile.22 Herein, we show that oral administration of a small synthetic molecule, such as AdipoRon, can also be key in counterbalancing excessive inflammatory and oxidative responses in the dystrophic muscle. This evidence concerns the gene ANPEP and Duchenne muscular dystrophy.