Ozawa T et al reported a trend towards higher expression of CCAT2 in patients with microsatellite stable (MSS) colorectal cancer (CRC) compared with microsatellite instable‐high (MSI‐H) CRC.14 Therefore, our findings supported our previous hypothesis that CASC21 might act as an oncogene in colon cancer. Here, CCAT2 is linked to malignant colon neoplasm.