SS18 and synovial sarcoma: These unique recurrent translocations were first discovered in the early 1990s by chromosomal banding techniques, for example, the t(X;18)(p11;q11) translocation in synovial sarcoma, which results in the tumor specific SS18‐SSX fusion genes.2 At the molecular level, with knowledge of the exon regions involved in fusion genes, RT‐PCR and Fluorescence In Situ Hybridisation (FISH, using break‐apart probes) methods became available to detect these particular gene fusions and rearrangements.