Association of the SNCA rs356219 A allele and MF is an unexpected finding because this variant has been associated with reduced PD susceptibility and older age at onset,29, 30, 31 as well as reduced plasma α‐synuclein levels in PD.32 Our observed association may reflect less severe diffuse α‐synuclein pathology in levodopa‐responsive patients who develop early MF, but it is a finding that requires further replication in an independent cohort. Here, SNCA is linked to Parkinson disease.