Most recent studies have focused on exogenous growth factors, including somatostatin,11 glutamine and growth hormone,12 epidermal growth factors,13 insulin-like growth factor-I,14 glucagon-like peptide 2,15 and hepatocyte growth factors.16 However, for some SBS patients, the residual intestines are critically short, therefore the outcomes are not very satisfactory. The gene discussed is EGF; the disease is macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss.