To determine the effect of XO inhibitors on diet-induced NASH, C57BL/6J mice were split into four groups and fed NC, the CL diet, or the CL diet supplemented with either 0.001% (w/w) febuxostat (CL + Feb) or 0.003% (w/w) allopurinol (CL + Allo) for 18 weeks. The gene discussed is XDH; the disease is metabolic dysfunction-associated steatohepatitis.