MTAP and central nervous system cancer: For pediatric gliomas, MTAP were more frequent in grade IV gliomas (62.5%, p = 0.0087) but rare in grade I gliomas (12.2%, p = 0.0178); besides, MTAP gene deletion was correlated with a poor survival (p = 0.01) and a shorter PFS (p = 0.016)26.