SDC1 and Miyoshi myopathy: Furthermore, we validated these in silico and in vitro findings by performing expression analysis of SENP2 from in-house MM clinical samples and found that SENP2 expression indeed significantly downregulated in CD138+ bone marrow cells of bortezomib resistant MM patient’s compared to bortezomib sensitive MM patient’s both at the RNA expression (Fig. 1E) and protein levels (Fig. 1F).