Finally, by using a cytokine array, we verified that the release of other chemokines and interleukins, such as IL6, IL8, CCL2, CCL5, known to be involved in crosstalk between CAF and cancer cells, was not statistically different between CAF-S1 and CAF-S4 (Supplementary Fig. 6i, j). Here, CCL5 is linked to cancer.