However, when we tested rs117028417 for genetic association with AD cerebrospinal fluid (CSF) Aβ and tau biomarkers, only nominal association of rs117028417 with total tau annual change could be discovered, and there was no association with baseline CSF Aβ and tau on both single SNP association tests and variant burden tests (Supplementary Tables 6, 7), indicating that FAM222A variant may not have a strong genetic influence on AD biomarkers. This evidence concerns the gene MAPT and Alzheimer disease.