APP and Alzheimer disease: Robust Aggregatin staining of the central core of amyloid deposits was consistently observed in the brains of multiple mouse models for AD including 5XFAD26, TgCRND827, APP/PS128, Tg257629, and 3xTg30 transgenic mice overexpressing human mutant APP along with or without human mutant PS1 (Fig. 2c, d and Supplementary Fig. 6f–h).