Previously reported AD top markers, APOE single nucleotide polymorphism (SNP) rs42935815, TOMM40 SNP rs207565015, APOC1 SNP rs1272105116, and rs117028417 on FAM222A were found in one module (Fig. 1, Supplementary Figs. 2, 3 and Supplementary Table 1), which consists of five ROIs including left hippocampus, right hippocampus, basal forebrain, entorhinal area, and planum polare, brain areas we know are affected by AD17–19 and well predict AD (Supplementary Fig. 4). The gene discussed is APOC1; the disease is Alzheimer disease.